Guillain-Barré syndrome is a rare condition that causes the immune system to attack the nerves outside of the brain and spinal cord. It is characterized by numbness, tingling, weakness, or paralysis in the legs, arms, breathing muscles, and face. It can affect all ages.
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The exact cause of Guillain-Barré syndrome is unknown. However in about three-fourths of people, a recent infection or surgery triggers an autoimmune response. This autoimmune response attacks the peripheral nerves, leading to weakness and a loss of sensation.
Guillain-Barré syndrome is more common in men, and in the those aged 15-35 years and 60-75 years old. Other factors that increase your chance of Guillain-Barré syndrome may include:
- Recent gastrointestinal or respiratory infection by viruses or bacteria
The swine flu vaccine given from 1976-1977 was linked to excess cases of Guillain-Barré syndrome. Since then,
influenza virus vaccines
have been associated with only a slight increased risk of Guillain-Barré syndrome.
- Recent surgery
systemic lupus erythematosus, or
- Recent treatment of cancer with immunotherapy
The first symptoms of Guillain-Barré syndrome include:
- Pain—the lower back pain is the most common complaint
- Progressive muscle weakness on both sides of the legs, arms, and face
- Prickly, tingling sensations, usually in the feet or hands
- Loss of normal reflexes
Symptoms may develop over a period of hours, days, or weeks. They will vary in severity from minimal to total paralysis including respiratory weakness. The symptoms progress and worsen. Most people experience the greatest weakness during the second or third week.
Related complications include:
- Facial weakness
- Blood pressure instability
- Heart rate changes
- Sweating abnormalities
- Urinary/gastrointestinal dysfunction
- Breathing difficulty
Most people fully recover, but others may have residual symptoms, or permanent or disabling problems.
You will be asked ask about your symptoms and medical history. A physical exam will be done.
Tests may include:
Treatment aims to reduce the body’s autoimmune response and decrease complications that result from immobility. Hospitalization is important because symptoms may rapidly become more severe, including respiratory failure, heart
arrhythmias, and blood pressure instability.
Common treatments include:
plasmapheresis, blood is removed from your body and passed through a machine that separates blood cells. The separated cells are then returned to your body with new plasma. This procedure may help shorten the course and severity of Guillain-Barré syndrome.
IV infusion with
(IVIg) may help reduce the severity of a Guillain-Barré attack. Immunoglobulins are proteins that are naturally produced by the body’s immune system.
In some cases, muscles necessary for breathing become paralyzed. This is treated with immediate emergency support from a mechanical ventilator.
Your doctor may advise
- Over-the-counter or prescription pain relievers
- Antiseizure medications
There are no current guidelines to prevent Guillain-Barré syndrome.
Guillain-Barre syndrome. EBSCO DynaMed Plus website. Available at: Available at:
http://www.dynamed.com/topics/dmp~AN~T116758/Guillain-Barre-syndrome. Updated April 28, 2017. Accessed February 14, 2018.
Vucic S, Kiernan MC, Cornblath DR. Guillain-Barre: an update.
J Clinical Neuroscience. 2009;16(6):733-741.
Last reviewed February 2018 by
EBSCO Medical Review BoardRimas Lukas, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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