Paget disease (PD) is a bone disorder. Normal bone is always being broken down and built again. With PD, bones are broken down too fast. New bone is loose and bulky instead of strong and compact. This leaves bones weak. They may bend over time.

PD affects the bones of the:

  • Pelvis
  • Legs
  • Skull
  • Spine

Normal Bone Structure

Bone Matrix
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The exact cause of PD is not known. It may due to a viral infection, such as the measles.

Risk Factors

PD is more common in people who are over 55 years old. It usually occurs in people of European descent.

Your risk for PD may also be higher if you:

  • Have a gene called SQSTM1
  • Have family members with PD, such as a parent, sibling, or child
  • Use tobacco


Most people with PD don't have symptoms. People who do may have:

  • Bone and joint pain
  • Misshapen bones
  • Hearing loss if PD is in the skull


You will be asked about your symptoms and health history. A physical exam will be done.

Your doctor will order blood tests.

Pictures will be taken of your body. This can be done with:


It is best to start treatment as soon as you can. Talk with your doctor about the best plan for you.

These are the medicines used to treat PD:

  • Pain relievers, such as acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs)
  • Bisphosphonates to prevent the loss of bone and keep the disease from getting worse

You may need surgery if you have:

There are things you can do to care for your PD:

  • Take calcium and vitamin D supplements.
  • Use assistive devices, such as canes and shoe lifts. They can help you if you have a limb that is too short.


There are no methods to prevent PD.

People with close family members who have PD should screened for the SQSTM1 gene.