Scleroderma is a lifelong disease. It causes damage to the structures that support and protect the body. It can cause skin and other structures to thicken and stiffen. This can happen in the skin, joints, and internal organs.

There are 3 types:

  • Localized—Involves the skin and other parts. The areas are not near each other.
    • Morphea—Made up of local patches.
    • Linear—Single line or band of skin that's thickened or discolored
  • Systemic (sclerosis)—Over a wider area of skin and organs (mainly the lungs). This type is more serious and can lead to death. Raynaud phenomenon (RP) is related to this type.
    • Limited—Sometimes called CREST syndrome:
      • Skin thickening happens slowly. This happens mostly on the hands, forearms, feet, and lower legs.
      • May progress to the organs.
    • Diffuse—
      • Happens quicker. It causes the skin to thicken throughout the body.
      • May progress to the organs.
    • Sclerosis sine scleroderma—Involves the organs, not the skin. This type is very rare.
  • Overlap syndrome—May involve features of scleroderma and other connective tissue syndromes.
  • Undifferentiated—Involves RP and some features of the systemic type.


The body makes too much collagen and other proteins. This causes changes in the skin, tissues, and organs. It’s not clear why this happens. The immune system may be too active, leading to the overproduction.

Risk Factors

Scleroderma is more common in women.

The most common age groups are:

  • Morphea—20-40 years old
  • Linear—mainly children
  • Systemic—30-50 years old

Your chances are also higher if you:

  • Have others in your family with the same types of problems
  • Are exposed to chemicals at work


Problems are contained to the skin. It doesn’t involve the organs. The skin problems may go away on their own. It may take a few months or years. For some, damage can be permanent. Skin problems may involve:

  • Hard patches on the skin, most often on the face or trunk—morphea
  • Lines of plaques or thickened skin
  • May spread to muscles or bones under the skin—linear
  • Muscle and joint aches, and fatigue—morphea

Systemic disease may be limited or diffuse. The limited type can start slowly. Most often, it involves RP. Cold or emotional stress cause swelling, numbness, and color changes in the fingers and toes. Over time, the skin may thicken.

Raynaud Phenomenon Symptom

Low blood flwo to fingers, vasoconstriction
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The diffuse type comes on faster. It spreads to the skin and organs. Other problems of this type:

  • The skin thickens and gets harder
  • Joint and muscle pain—there may also be stiffness and swelling
  • Breathing problems
  • Swallowing problems
  • Blood vessels thicken and swell

The diffuse type can cause problems all over the body. This may involve:


The doctor will ask about your symptoms and health history. Your answers and a skin exam will point to scleroderma. You may also have:


There is no cure for scleroderma. Care focuses on easing symptoms.

Your doctor may advise these or other medicines to treat:

Other care may involve:

  • Physical therapy and exercise to help with circulation, flexibility, and strength
  • Phototherapy—to thin out the skin
  • Changes to control GERD such as eating smaller meals or raising the head of your bed
  • Quitting smoking to improve blood flow


There is no way to prevent scleroderma because the exact cause is unknown.