Lymph nodes are found throughout the body. They are part of the body’s immune system. These nodes help fight infection by producing special white blood cells. They also work by trapping bacteria, viruses, and cancer cells. Normally, lymph nodes cannot be felt unless they are swollen. Infection, usually by a virus, is the most common cause of lymph node swelling. Other causes include bacterial infection and cancer.

With this type of biopsy, the doctor removes all or part of a lymph node so it can be further examined.

Reasons for Procedure

This biopsy is done to find out why a node is swollen. Swelling may be caused by infection, cancer, or another disease such as sarcoidosis.

Common areas for biopsy include:

  • Groin
  • Armpit
  • Neck
  • Under the jaw and chin
  • Behind the ears

Possible Complications

Problems from the procedure are rare, but all procedures have some risk. Your doctor will review potential problems, like:

  • Bleeding
  • Infection
  • Swelling
  • Nerve damage, including numbness at the biopsy site, which usually resolves in a few months

What to Expect

Leading up to your procedure, you will need to:

  • Talk to your doctor about your medical history, including:
    • Any allergies that you have
    • Any medications you take, including over-the-counter drugs and herbs and supplements. You may be asked to stop taking some medications up to 1 week before the procedure.
  • Arrange for a ride home from the care center.
  • Avoid eating or drinking anything after midnight if you will have general anesthesia.
  • Local anesthesia—Just the area that is being operated on is numbed.
  • General anesthesia is used for open biopsies—General anesthesia blocks pain and keeps you asleep through the procedure.

Lymph nodes samples can be obtained by:

  • Needle biopsy
  • Open biopsy

There are 2 types of needle biopsies:

  • Fine needle biopsy—A thin, hollow needle is used to obtain tissue samples.
  • Core needle biopsy—A larger needle is used to cut out a piece of tissue.

An ultrasound or CT scan may be used to help locate the biopsy site.

Lymph Node Biopsy

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An open biopsy means removing the lymph nodes through an incision. A cut will be made in the skin. All or part of a lymph node will be removed. After removal, the incision will be closed with stitches and bandaged.

The sample will be sent to the lab for examination.

About 30-60 minutes—longer if an ultrasound or CT scan is used

You will have some pain and tenderness after the biopsy is taken. Your doctor may give you pain medication.

Be sure to follow your doctor's instructions. Results will be ready in about a week. Your doctor will tell you if further treatment is needed.

Call Your Doctor

Call your doctor if any of these occur:

  • Signs of infection, including fever and chills
  • Redness, swelling, increasing pain, excessive bleeding, or any discharge from the incision site
  • New or unexpected symptoms

If you think you have an emergency, call for emergency medical services right away.